Cinnamon: The Prevention of Insulin Resistance in Type 2 Diabetes

-
Cinnamon (Cinnamomum verum, C. zeylanicum) and cassia (C. aromaticum) have a long history of uses as spices, flavoring agents, preservatives, and pharmacological agents.

Cinnamon Increases Insulin Sensitivity and Glucose Transport

Insulin resistance is a core defect in obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome.
Many data tell that Cinnamon Extract (CE) prevents the development of insulin resistance, by enhancing insulin signaling and possibly via the NO pathway in skeletal muscle. An aqueous extract of cinnamon has also been shown to improve insulin sensitivity in humans.
Previous studies reported that CE increases glucose uptake and the glucose transporter (GLUT4) expression in adipose cells. It has been observed that a water extract of cinnamon reduced blood glucose, plasma insulin.

Cinnamon Decreases Inflammation

Tristetraprolin is an anti-inflammatory protein and a potential therapeutic target for the treatment of inflammation related diseases. It has been reported that tristetraprolin may offer partial protection against the development of insulin resistance and diabetes.
CE rapidly induces the expression of tristetraprolin mRNA levels in adipocytes. Cinnamon extract treatment decreases the mRNA expression of the inflammatory factors; improves the mRNA expression of IR, IRS1, IRS2, PI3K, and Akt1; inhibits CD36, microsomal triglyceride transfer protein (MTP), and phosphatase and tensin homolog; and enhances impaired sterol regulatory element-binding protein (SREBP)-1c expression in TNF-α- treated enterocytes. That study suggested that CE helps prevent the elevation of circulating triglyceriderich lipoproteins with significant effects on intestinal insulin resistance. Cinnamon extract reduces inflammation-related dyslipidemia and decreases risk factors associated with cardiovascular diseases.

Cinnamon Controls Vascular Endothelial Growth Factor (VEGF) and Decreases Proliferation of Cancer Cells

Vascular endothelial growth factor is also a key mediator of adipogenesis in obesity and insulin resistance. However, most current anti-VEGF agents often cause side effects and therefore cannot be recommended for long-term use.
Cinnamon extract inhibits VEGF-induced endothelial cell proliferation, migration, and tube formation in vitro, sprouts formation from aortic ring ex vivo, and tumor-induced blood vessel formation in vivo. These data suggest that procyanidin oligomers are active components in CE that inhibit angiogenesis. Taken together, this study revealed novel activity in cinnamon and identified a natural inhibitor of VEGF signaling that could potentially be useful in cancer prevention and/or treatment.

Cinnamon Improves Glucose, Insulin, Blood Lipids, and Hemoglobin A1c of People with Type 2 Diabetes

Many studies demonstrating that cinnamon improves blood glucose, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in people with T2DM. It is also reported decreased fasting and postprandial glucose due to CE. Other study reported that cinnamon lowered hemoglobin A1c (HbA1c 0.83%) compared with usual care alone (0.37%).
Another study concluded that the effects of supplemental cinnamon on HbA1c values were only slightly less than the placebo-adjusted reductions reported for two popular drugs, sitagliptin and saxagliptin, used in the treatment of T2DM. However, cinnamon is without known side effects and can be used to treat more than 25 times as many patients for the same amount of money.

For more information regarding the study. Please click here.

Or Contact me at:
Robert Khuc
>>> Commitment & Responsibilities <<<
TIEN THANH AGRICULTURAL PRODUCTION COMPANY LIMITED
Mobile: (+84) 98 121 7643

Comments

Post a Comment

Get your weekly offer

* indicates required

Popular posts from this blog

CASSIA CINNAMON VOLATILE OIL RATE QUICK TABLE

-
Image
The table for Volatile Oil percentage in each part of Cassia Cinnamon Tree. Cassia Cinnamon Parts Volatile Oil (VO) Note Cork (Skin) 0.7% For low VO Broken or Powder Twig 2% For low VO Broken or Powder Leaf 1 - 2% For Powder Branch 2 - 3.5% For Broken or Powder Forest Cassia (Fixed Oil Cassia) [Non-preferable and Limited supply] 2% max For low VO Broken or Powder (Sometime for Stick Cassia in case you need cheap one for decorative purpose only) Grade C Age: 5-12 years Thickness: 2.5 mm max 3 - 3.5% For Split, Pressed, Broken Grade B Age: 12-20 years Thickness: 2.5-4 mm 3 - 3.5% For Tube, Square, Round, Broken, Stick, Chips   Skinless (without cork) 4% and above Grade A ...
Read more

TRUE CASSIA VS FOREST CASSIA

-
Image
If you are truly wondering why there is so much difference in price of Cassia Cinnamon between suppliers in Vietnam, even they claim to have the same quality, this article is for you. Forest Cassia, a specie that looking so much Cassia Cinnamon but not Cassia Cinnamon. Being harvested in the Forest, which is protected by the law and government. Mixing in all kinds of Cassia Cinnamon (from broken to split or even stick cassia) to reduce the price. Mixing these Fake Cassia and True Cassia, intentional or unintentional, this will definitely result in a bad habit, which will be harmful for our reputation and gradually damage the experience of our end users. So let’s have a quick check on the differences between these two. Cork (Skin) Color: Same Without Cork Color: They look pretty identical to each other. The below picture is featuring both Forest Cassia and True Cassia. Can you pick them out? Oil Line: Forest Cassia’s Oil Line is deep dark. True Cassia’s Oil Line is lighter in color. W...
Read more

CASSIA CINNAMON POWDER COLOR + BONUS ROUND

-
Image
Cassia powder color, will you able to tell anything from the color of your cassia cinnamon powder? Yes, you will. But not too much. For example, taking out these samples: You got VO 1.5% is the darkest powder, also less yellowish and more grayish. VO 2.5% and 3% are brighter and more yellow in side. However, the VO 4% cassia powder is a bit darker compare to 2.5% and 3%. So the theory that said “the brighter the color is, the higher the VO is”, is not correct this time. Then, what should be the case? For cassia powder making, the color is highly depended on the available of materials at the time of processing. As well as the way they are mixed. And the requirements of customer in order to optimize the cost and price. The brightness of your cassia powder should look like on these. Brighter Darker Without cork With cork Leaves available Leaves unavailable Doesn’t mean higher VO (volatile oil) Doesn’t mea...
Read more